Monitoring of brain function in high-risk neonates -- amplitude integrated electroencephalography monitor

With the development of neonatal intensive care technology and the improvement of obstetric delivery technology, the survival rate of premature infants and high-risk neonates increased significantly, but the incidence of neonatal brain injury and cerebral palsy in children did not decrease correspondingly, suggesting that it is difficult to diagnose and treat the brain injury of premature infants and high-risk neonates. . The incidence of neonatal brain injury is high and the condition is serious in our country. Most hospitals have no conditions to carry out routine EEG examination at bedside, nor can they carry out CT and MRI examination at an early stage. Therefore, it is urgent to develop a simple, convenient bedside monitoring and reasonable price brain function monitoring tool so as to make clinical diagnosis as soon as possible. Premature infants and children with brain injury need timely intervention to improve their prognosis. Electroencephalograph

Amplitude-integrated electroencephalogram (aEEG) is a newly developed clinical electroencephalogram monitoring technique for newborns. It is a simplified and single-lead electrophysiological monitoring. Since 1980s, aEEG has been gradually applied to the pediatric field. With the development of computer technology, aEEG gradually realizes the real-time conversion between the amplitude band and the original EEG, which is more convenient for clinical application and analysis. In recent years, aEEG has gradually become a research hotspot in the field of neuroelectrophysiology, and is also concerned by pediatric clinicians. This technique can not only reflect the changes of background activity, but also reflect epileptiform activity. It has the characteristics of simple operation, less environmental interference, easy interpretation and long-term bedside continuous monitoring. In addition, the new digital amplitude-integrated EEG monitor can also record both aEEG and standard EEG using a variety of electrodes and leads. Therefore, the application of aEEG for continuous monitoring of brain function has become a part of routine monitoring in neonatal intensive care unit abroad; it has great value in assessing the maturity of neonatal brain development, diagnosis and prognosis of neonatal convulsion, brain injury.

AEEG testing technology has been increasingly used in neonatal intensive care units, and a large number of papers have been published to evaluate the various aspects of aEEG. A meta-analysis published in recent years assessing the prognostic value of aEEG in full-term neonates with asphyxia has concluded that aEEG is valuable in predicting the long-term prognosis of asphyxiated neonates. It is recommended as part of the initial assessment of all perinatal asphyxia neonates. Bedside aEEG monitoring can also help clinicians understand and follow up the brain development and maturation disorders in premature infants.Meilun

MeilunElectroencephalograph: The study of aEEG in the field of neonates in China started relatively late. As an important means of neonatal brain function monitoring, aEEG has gradually been known and recognized by the industry. In 2014, a new type of digital amplitude integrated electroencephalogram monitor was introduced into the neonatal department of the Affiliated Hospital of Guilin Hospital. It became one of the few units in Guangxi that possessed the equipment and related technology. The deputy director of the neonatal department, Dr. Zhang Hua, introduced that aEEG has a very high and wide application value in the field of neonates: 1. It is used for brain maturity. Especially for preterm infants. 2. To evaluate the degree of neonatal brain injury. 3. To evaluate the prognosis of neonatal brain injury. 4. The evaluation of neonatal convulsion. 5. It has special value in the evaluation of brain injury in premature infants. The latest "Diagnostic Criteria for Neonatal Hypoxic-Ischemic Encephalopathy" also suggests that EEG should be used as a prognostic reference within one week after birth. With the further study and clinical application, combined with the characteristics of simple, non-invasive, less environmental interference, it is believed that aEEG in the field of neonates will have a broader application prospects, improve the prognosis of high-risk neonates.Meilun